Heroin | 6-MAM | Morphine | M3G | M6G | |
---|---|---|---|---|---|
Repeated heroin | |||||
2.5 mg/kg × 10 | 1.2 ± 0.1 | 1.4 ± 0.3 | 0.5 ± 0.2 | 0.5 ± 0.1 | 0.06 ± 0.05 |
5.0 mg/kg × 10 | 1.3 ± 0.02 | 1.8 ± 0.1 | 0.6 ± 0.1 | 0.8 ± 0.1 | 0.08 ± 0.08 |
10 mg/kg × 10 | 1.8 ± 0.05 | 2.4 ± 0.3 | 1.2 ± 0.2 | 0.6 ± 0.1 | 0.07 ± 0.06 |
Repeated morphine | |||||
10 mg/kg × 10 | n.d. | n.d. | 2.5 ± 0.5 | 1.3 ± 0.2 | n.d. |
20 mg/kg × 10 | n.d. | n.d. | 2.4 ± 0.1 | 1.3 ± 0.03 | n.d. |
40 mg/kg × 10 | n.d. | n.d. | 2.8 ± 0.4 | 1.7 ± 0.1 | n.d. |
n.d., not detectable.