TABLE 1
Pharmacokinetic and receptor dynamic parameters
Parameter | Value |
|---|---|
| Pharmacokinetics (fixed) | |
| C1 (ng/ml) | 39,130 |
| C2 (ng/ml) | 12,670 |
| λ1 (h-1) | 7.54 |
| λ2 (h-1) | 1.20 |
| Receptor dynamics (fixed) | |
| ks_Rm (fmol/g liver/h) | 2.90 |
| IC50_Rm (fmol/mg of protein) | 26.2 |
| kon (l/nmol/h) | 0.00329 |
| kT (h-1) | 0.63 |
| kre (h-1) | 0.57 |
| Rf | 0.49 |
| kd_R (h-1) | 0.0572 |
 (fmol/g liver) | 25.8 |
| R0 (fmol/mg protein) | 540.7 |