TABLE 2

Potency of test agonists measured as D50 valuesa


Agonist

D50, Mean ± S.D. (n)
Histamine 4.7 ± 2.4 nmol (5)
LTC4 10 ± 4 pmol (7) vs. LTD4**
LTD4 3 ± 0.2 pmol (5) vs. Histamine**
LTE4 24 ± 15 pmol (4) vs. LTD4*
LTD4 after 10 μM diclofenac 96 ± 43 pmol (5) vs. LTD4**
U-46619
43 ± 15 pmol (4) vs. LTD4***
  • n, number of subjects; *P < 0.05, **P < 0.01, ***P < 0.001.

  • a D50, the agonist dose causing 50% decrease in conductance.