Comparison of ECG parameters from nicotine-treated Kcnq 1+/+ and Kcnq 1−/− mouse hearts
ECG Parameters: Nicotine (100 μM) | Kcnq 1+/+ | Kcnq 1−/− | p Value |
|---|---|---|---|
| n = 4a | n = 5b | ||
| RR (ms) | 142 ± 11 | 148 ± 12 | 0.47 |
| PR (ms) | 31 ± 6 | 40 ± 17 | 0.35 |
| QRS (ms) | 9 ± 7 | 12 ± 8 | 0.57 |
| QT (ms) | 79 ± 4 | 111 ± 11 | <0.001 |
| QTc (ms) | 66 ± 2 | 92 ± 11 | <0.01 |
| JT (ms) | 69 ± 5 | 102 ± 11 | <0.001 |
|
T-Wave area (mV · ms × 10−1)
|
291 ± 111
|
530 ± 340
|
0.22
|
↵ a No analysis was obtained for 2 of the 6 Kcnq 1+/+ hearts following nicotine treatment because of persistent atrioventricular block (recovered after several minutes).
↵ b No analysis was obtained for 1 of the 6 Kcnq 1−/− hearts following nicotine treatment due to development of ventricular tachycardia (recovered after ∼1 min).