TABLE 1

Plasma nicotine and cotinine levels after s.c. injections of 0.001 to 1.0 mg/kg nicotine Rats were sacrificed at 4 h after last nicotine treatment. Data are means ± S.D. of three animals in each treatment group.


Nicotine Dose

Plasma Levels

Nicotine
Cotinine
mg/kg s.c ng/ml
0.001 <1.5 <1.5
0.003 <1.5 <1.5
0.005 <1.5 4.0 ± 1.0
0.01 <1.5 7.7 ± 1.53
0.02 <1.5 10.0 ± 1.0
0.03 <1.5 10.0 ± 2.65
0.1 1.6 ± 0.6 24.3 ± 2.08
1.0
19.7 ± 1.3
272.0 ± 28.2