Haplotype structure of the UGT1 gene in subjects with the UGT1A9*3 polymorphism
Haplotypes were analyzed only in patients carrying the M33T polymorphism in the UGT1A9 first exon. Thus, subjects with any other combination of polymorphic sites were not included in this analysis. A number of additional haplotypes characterized by the absence of a variant UGT1A9*3 allele were also observed in the population studied.
Caucasian Subjects | Designated Haplotype | Functional Polymorphisms Associated with a Decreased Rate of SN-38 Glucuronidation | ||||
|---|---|---|---|---|---|---|
| UGT1A9 Codon 33 | UGT1A7 Codon 208 | UGT1A1 A(TA)nTAA Promoter | ||||
| American | ||||||
| 1 | I | 1 | 0 | 0 | ||
| 2 | II | 1 | 0 | 1 | ||
| 3 | II | 1 | 0 | 1 | ||
| French Canadian | ||||||
| 4 | I | 1 | 0 | 0 | ||
| 5 | I | 1 | 0 | 0 | ||
| 6 | I | 1 | 0 | 0 | ||
| 7 | I | 1 | 0 | 0 | ||
| 8 | II | 1 | 0 | 1 | ||
| 9 | III | 1 | 1 | 1 | ||
| 10 | III | 1 | 1 | 1 | ||
| 11 | III | 1 | 1 | 1 | ||
| 12 | III | 1 | 1 | 1 | ||
0, homozygous wild type; 1, heterozygous; 2, homozygous variant.