Compound  i.v. Parameter  Oral Andriol Group (n = 4)  Oral Andriol Testocaps Group (n = 4)  p Value^{a}  Combined i.v. Data^{b} (n = 8) 

[^{2}H]TU  C_{max} (nM)  1,250 ± 116  1,217 ± 77  0.81  1,234 ± 65 
AUC^{0∞} (nM · min)  36,137 ± 3,835  36,720 ± 2,089  0.90  36,429 ± 2,024  
t_{1/2} (min)  15.2 ± 0.7  16.4 ± 0.7  0.25  15.8 ± 0.5  
CL (l/min)  0.228 ± 0.022  0.218 ± 0.012  0.70  0.222 ± 0.012  
V_{D} (l)  4.98 ± 0.50  5.17 ± 0.44  0.78  5.08 ± 0.31  
[^{2}H]T  C_{max} (nM)  74.3 ± 6.5  81.1 ± 5.3  0.44  77.7 ± 4.1 
t_{max} (min)  25 ± 5  26 ± 4  0.90  26 ± 3  
AUC^{0∞} (nM · min)  5,187 ± 452  5,746 ± 261  0.33  5,466 ± 264  
t_{1/2} (min)  32.3 ± 4.5  31.8 ± 3.5  0.93  32.1 ± 2.7  
[^{2}H]DHT  C_{max} (nM)  6.3 ± 1.3  9.3 ± 1.4  0.16  7.8 ± 1.1 
t_{max} (min)  42 ± 11  37 ± 6  0.68  49 ± 6  
AUC^{0∞} (nM · min)  418 ± 73  760 ± 145  0.08  589 ± 99  
 t_{1/2} (min)

38.7 ± 11.7

36.3 ± 4.7

0.86

37.5 ± 5.8

↵ a p values are the result of the twotailed Student's t test of the mean parameter estimates between the two formulations.
↵ b The mean ± S.E. values for all study dogs (n = 8) was calculated because there was no statistically significant difference (p > 0.05) between Andriol and Andriol Testocaps for any of the measured parameters.