Pharmacokinetic parameters obtained in two-compartment model. The plasma inhibitor concentration versus time curve was analyzed by nonlinear least squares program.
Compound | Vc | Vss | CL |
|---|---|---|---|
| l/kg | l/kg | l/h/kg | |
| C2C2 | 0.799 | 1.063 | 15.274 |
| C8C2 | 4.183 | 10.968 | 9.344 |
| C12C2 | 0.465 | 0.787 | 2.851 |
| C14C2 | 0.080 | 0.140 | 0.292 |
| C16C2 | 0.061 | 0.064 | 0.119 |
|
C18C2
|
0.067
|
0.130
|
0.034
|