AMPA receptor binding after 4 weeks of continuous infusion of antipsychotic drugs
Data are mean ± S.E.M. values for binding [fentomoles per milligram of tissue and (percentage of control)], determined by quantitative autoradiography after continuous subcutaneous infusion of vehicle or antipsychotic drugs for 4 weeks with significant differences from controls indicated by *p < 0.05 (n = 6 rats/group), all as described under Materials and Methods.
Brain Region | Controls | Olanzapine | Risperidone | Quetiapine | Clozapinea | Haloperidola |
|---|---|---|---|---|---|---|
| Cerebral cortex | ||||||
| Medial-prefrontal | 437 ± 11.4 (100) | 434 ± 23.7 (99) | 454 ± 16.2 (104) | 475 ± 18.2 (109) | (96) | (102) |
| Dorsolateral | 382 ± 4.4 (100) | 376 ± 29.4 (98) | 380 ± 14.9 (99) | 380 ± 16.3 (99) | (94) | (90) |
| Entorhinal cortex | 435 ± 10.1 (100) | 416 ± 8.5 (96) | 464 ± 9.4 (107) | 453 ± 18.2 (104) | (112) | (101) |
| Hippocampus | ||||||
| CA1 region | 650 ± 12.3 (100) | 633 ± 21.3 (97) | 673 ± 14.1 (104) | 672 ± 18.4 (103) | (106) | (102) |
| CA3 region | 448 ± 11.5 (100) | 422 ± 19.0 (94) | 454 ± 16.9 (101) | 453 ± 22.6 (101) | (117) | (116) |
| Nucleus accumbens | 434 ± 12.0 (100) | 438 ± 18.4 (101) | 446 ± 13.0 (103) | 461 ± 14.2 (106) | (100) | (99) |
| Caudate-putamen | ||||||
| Medial | 282 ± 5.3 (100) | 335 ± 13.1 (119)* | 365 ± 21.0 (130)* | 356 ± 25.2 (126)* | (102) | (97) |
|
Lateral
|
284 ± 4.3 (100)
|
352 ± 12.6 (124)*
|
373 ± 24.2 (131)*
|
366 ± 24.5 (129)*
|
(109)
|
(107)
|
↵ a Data (percentage of control) for clozapine (25 mg/kg/day) and haloperidol (1.5 mg/kg/day) were determined previously (Tarazi et al., 1996) and are shown for comparison.