Effects of endocyclic modifications in U-II on the rat thoracic aorta
Peptide | Structure | Rat Thoracic Aorta Bioassay | ||||
|---|---|---|---|---|---|---|
|
EC50 ±
SEMa | Emax ±
S.E.M.b | n
c
| ||||
| nM | % | |||||
| 1 | ETPDCFWKYCV (hU-II) | 3.3 ± 0.3 | 98 ± 3 | 12 | ||
| 13 | ETPDCAWKYCV | 1,900 ± 300 | 67 ± 12 | 4 | ||
| 14 | ETPDCFAKYCV | >10,000 | N.D. | 4 | ||
| 15 | ETPDCFWAYCV | >10,000 | N.D. | 4 | ||
| 16 | ETPDCFWKACV | >10,000 | N.D. | 4 | ||
| 18 | ETPDC-WKYCV | >1,000 | N.D. | 4 | ||
| 19 | ETPDCF-KYCV | >10,000 | N.D. | 4 | ||
| 20 | ETPDCFW-YCV | >10,000 | N.D. | 3 | ||
| 21 | ETPDCFWK-CV | >10,000 | N.D. | 4 | ||
| 22 | ETPDCfWKYCV | >1,000 | N.D. | 6 | ||
| 23 | ETPDCFwKYCV | 170 ± 50 | 37 ± 3 | 8 | ||
| 24 | ETPDCFWkYCV | >10,000 | N.D. | 4 | ||
| 25 | ETPDCFWKyCV | >10,000 | N.D. | 4 | ||
| 28 | ETPDCFHKYCV | 2,600 ± 420 | 52 ± 13 | 6 | ||
| 32 | ETPDCFWRYCV | 69 ± 15 | 64 ± 14 | 8 | ||
| 33 | ETPDCFWOrnYCV | >10,000 | N.D. | 4 | ||
| 35 | ETPDCFWKFCV | 35 ± 2 | 64 ± 14 | 8 | ||
| 36 | ETPDCYWKYCV | 40 ± 4 | 83 ± 5 | 9 | ||
| 41 | ETPDCFPKYCV | >10,000 | 69 ± 3 | 4 | ||
| 29 | ETPDCAFWKYCV | 2,660 ± 1,300 | 34 ± 4 | 7 | ||
|
40
|
ETPDCFKYWCV
|
>10,000
|
N.D.
|
5
| ||