Cell | Receptor | Readout | IC50 (n) |
---|---|---|---|
nM | |||
RBL-2H3 | Fc∈RI | Hexosaminidase | 46±19 (4) |
Rat peritoneal mast cells | Fc∈RI | Serotonin | 17±14 (4) |
HCMC | Fc∈RI | Histamine | 5.1±1.2 (4) |
HCMC | Fc∈RI | Tryptase | 5.5±1.5 (4) |
HCMC | Fc∈RI | PGD2 | 5.8±1.3 (4) |
HCMC | Fc∈RI | LTs | 3.3±0.3 (3) |
HCMC | Fc∈RI | GM-CSF | 200±40 (4) |
Human leukocytes from high IgE donors | Fc∈RI | Histamine | 8.1±6.1 (3) |
Human leukocytes from low IgE donors | Fc∈RI | Histamine | 10.2±5.2 (7) |
Ramos | BCR | [Ca2+]i | 81±29 (6) |
Mouse splenic B cells | BCR | Proliferation | 58±26 (4) |
Mouse eosinophils | FcγR | Superoxide | 35±14 (3) |
U937 | FcγRI | Superoxide | 52±14 (4) |
Human fresh monocytes
|
FcγR
|
Superoxide
|
12±7 (4)
|