NDDPI does not inhibit electrical field stimulation-evoked [3H]overflow from [3H]DA preloaded striatal slices
Superfusion buffer contained pargyline (10 μM) and nomifensine (10 μM). Slices were superfused with a range of NDDPI concentrations. Each slice was exposed to only one concentration of NDDPI and subsequently was stimulated with 120 pulses (1 Hz) of electrical field stimulation. Data represent [3H]overflow during the 60-min period of superfusion following electrical field stimulation.
NDDPI | 120 Pulses |
|---|---|
| μM | |
| Control (0) | 2.24 ± 0.35a |
| 0.001 | 1.47 ± 0.28 |
| 0.01 | 2.45 ± 0.39 |
| 0.1 | 2.23 ± 0.36 |
|
1.0
|
1.23 ± 0.38
|
↵ a Data are mean ± S.E.M. of total [3H]overflow expressed as a percentage of tissue tritium. n = 6 rats.