TABLE 1

Oral dose response of LY503430 on four measures of efficacy after unilateral infusion of 6-OHDA into the substantia nigra

The data in Table 1 was collected in three independent experiments and, to allow comparison between experiments, are tabulated in terms of significance within experiments. Each experiment has vehicle-treated animals as control, and data are based on eight animals per group. Results are p values calculated after analysis of variance followed by appropriate post hoc t test.


Dose

TH Ventral

TH Dorsal

Rotation Score

GAP-43
mg/kg
0.05 N.S. p < 0.05 N.S. p < 0.05
0.1 p = 0.052 p < 0.05 p < 0.01 p < 0.01
0.2 p < 0.05 p < 0.01 p < 0.01 p < 0.01
0.5
p < 0.01
p < 0.01
p < 0.01
p < 0.01
  • N.S., nonsignificant.

    ** If the data were analyzed together then the minimal effective dose is 0.05 mg/kg.