TABLE 2

Regional myocardial blood flow during coronary artery occlusion and reperfusion

CAO-1, 3 to 5 min after coronary artery occlusion; CAO-2, before coronary artery reperfusion; CAR, 5 to 8 min after coronary artery reperfusion.

Control
CAO-1
CAO-2
CAR
Nonischemic region
Endomyocardial (ml/min/g)
    Vehicle (n = 6) 0.73 ± 0.05 0.77 ± 0.08 0.98 ± 0.10 0.98 ± 0.14
    GHRP-6 (n = 8) 1.06 ± 0.11 0.89 ± 0.07 1.10 ± 0.12 1.05 ± 0.13
    GH (n = 4) 0.90 ± 0.10 0.91 ± 0.04 1.18 ± 0.09 1.04 ± 0.09
Midmyocardial (ml/min/g)
    Vehicle (n = 6) 0.59 ± 0.04 0.65 ± 0.07 0.85 ± 0.08 0.84 ± 0.13
    GHRP-6 (n = 8) 0.91 ± 0.11 0.78 ± 0.07 0.96 ± 0.09 0.97 ± 0.12
    GH (n = 4) 0.78 ± 0.10 0.79 ± 0.07 1.09 ± 0.09 0.97 ± 0.03
Epimyocardial (ml/min/g)
    Vehicle (n = 6) 0.51 ± 0.02 0.60 ± 0.07 0.78 ± 0.10 0.72 ± 0.12
    GHRP-6 (n = 8) 0.69 ± 0.07 0.65 ± 0.04 0.80 ± 0.05 0.79 ± 0.08
    GH (n = 4) 0.61 ± 0.04 0.68 ± 0.05 0.94 ± 0.08 0.75 ± 0.03
Ischemic region
Endomyocardial (ml/min/g)
    Vehicle (n = 6) 0.67 ± 0.04 0.04 ± 0.01* 0.08 ± 0.01* 1.76 ± 0.15*
    GHRP-6 (n = 8) 0.97 ± 0.11 0.05 ± 0.01* 0.05 ± 0.01* 1.18 ± 0.18
    GH (n = 4) 0.80 ± 0.06 0.06 ± 0.01* 0.06 ± 0.01* 1.96 ± 0.46
Midmyocardial (ml/min/g)
    Vehicle (n = 6) 0.63 ± 0.03 0.07 ± 0.02* 0.17 ± 0.04* 1.94 ± 0.24*
    GHRP-6 (n = 8) 0.84 ± 0.10 0.08 ± 0.01* 0.11 ± 0.01* 1.56 ± 0.17*
    GH (n = 4) 0.72 ± 0.04 0.06 ± 0.01* 0.10 ± 0.01* 1.53 ± 0.24
Epimyocardial (ml/min/g)
    Vehicle (n = 6) 0.50 ± 0.01 0.12 ± 0.04* 0.27 ± 0.08* 1.01 ± 0.15*
    GHRP-6 (n = 8) 0.65 ± 0.05 0.12 ± 0.02* 0.20 ± 0.03* 1.34 ± 0.21*
    GH (n = 4)
0.56 ± 0.07
0.11 ± 0.02*
0.17 ± 0.05*
1.06 ± 0.40

  • ↵* p < 0.05 vs. control.