TABLE 1

Anti-inflammatory effects of KPV and MS05 in IL-1β-induced inflammation in recessive yellow (e/e) mice

Mice were treated s.c. with KPV (9 nmol), MS05 (6.6 nmol), or PBS (100 μl) 30 min before i.p. injections of IL-1β (10 ng in 0.5 ml of sterile PBS); PMN migration and KC release were assessed at the 4 h timepoint. Data are mean ± S.E. of n = 5 mice/group.


Treatment

PMN

KC
106 per mouse pg/ml
PBS 4.2 ± 0.4 239.2 ± 37.7
KPV 3.2 ± 0.3* 251.2 ± 54.8
MS05
2.7 ± 0.3*
255.0 ± 26.8
  • * P < 0.05 versus PBS group.