TABLE 4

Effect of preemptive and post-injury administration of minocycline (40 mg/kg) on the cytokines levels in the L5 lumbar spinal cord of the L5 spinal nerve-transected rats

Values are picograms per milligram of total protein ± S.E.M. (n = 4).

	Sham	Saline	Minocycline (40 mg/kg) Treatment
	Sham	Saline			Preemptive	Postinjury
IL-1β	39.5 ± 4.8	208 ± 18.4^a	88.5 ± 12.3^a,^b	143.5 ± 18.5^a,^c
IL-6	201 ± 19	698 ± 61^a	306 ± 28^a,^b	654 ± 43^a
TNF-α	22.5 ± 3.1	98.5 ± 13^a	36 ± 11.8^a,^b	54.5 ± 15.2^a,^c

↵ a p < 0.01 vs. sham; ^bp < 0.01; and ^cp < 0.05 vs. saline-treated group.