TABLE 1

Effect of BN 80933 on physiologic variables

MABP, PaCO2, PaO2, and pH were measured before and after treatment with BN 80933 (3 and 10 mg/kg, i.v.) or its vehicle. There were no significant differences between groups. Values are means ± S.E.M. (n = 5-8 per group).

Vehicle
BN 80933
3 mg/kg
10 mg/kg
MABP (mm Hg)
    Before treatment 98 ± 2 94 ± 7 96 ± 7
    30 min after treatment 100 ± 3 90 ± 6 89 ± 9
    60 min after treatment 98 ± 4 88 ± 5 94 ± 7
    90 min after treatment 94 ± 4 87 ± 3 93 ± 11
    120 min after treatment 88 ± 8 83 ± 5 90 ± 9
PaO2 (mm Hg)
    Before treatment 108 ± 3 108 ± 3 108 ± 3
    30 min after treatment 108 ± 2 100 ± 3 108 ± 6
    60 min after treatment 111 ± 6 107 ± 4 108 ± 4
    120 min after treatment 113 ± 7 116 ± 6 108 ± 2
PaCO2 (mm Hg)
    Before treatment 35.8 ± 3.6 35.8 ± 3.6 35.8 ± 3.6
    30 min after treatment 36.8 ± 1.3 37.9 ± 1.3 41.4 ± 1.2
    60 min after treatment 38.2 ± 2.7 38.1 ± 1.6 35.9 ± 2.4
    120 min after treatment 36.6 ± 2.4 39.1 ± 2.4 40.1 ± 2.8
pH
    Before treatment 7.32 ± 0.04 7.32 ± 0.04 7.32 ± 0.04
    30 min after treatment 7.35 ± 0.02 7.37 ± 0.01 7.31 ± 0.03
    60 min after treatment 7.35 ± 0.02 7.32 ± 0.02 7.39 ± 0.02
    120 min after treatment
7.37 ± 0.02
7.31 ± 0.03
7.36 ± 0.03