TABLE 1
Pharmacokinetic parameters determined from simultaneous fitting of eqs. 3 and 4 to plasma level data acquired before and after bone marrow ablation
VM/KM | K |  | CL | ||||
|---|---|---|---|---|---|---|---|
| Pre-Ablation | Post-Ablation | ||||||
| 1/h | ml/h/kg | ||||||
| Newborn | |||||||
| Mean | 1.10 | 0.498 | 0.309 | 118 | 39.8 | ||
| CV% | 15.8 | 33.2 | 25.3 | 10.9 | 40.8 | ||
| Adult | |||||||
| Mean | 1.30 | 0.128 | 0.0895 | 67.8 | 7.62 | ||
| CV% | 3.81 | 17.9 | 18.4 | 19.3 | 39.8 | ||
| Ho: Newborn = Adult: | p > 0.05 | p < 0.05 | p < 0.05 | p < 0.01 | p < 0.05 | ||
| Ho: CL before = CL after: |
|
|
| p < 0.01 | p < 0.01 | ||