Effects of selective receptor antagonists
Values were obtained 10 min postdrug administration.
Drug | Change in MAP | Change in HR | Change in CO | Change in SV | Change in SVR | Change in HqR |
|---|---|---|---|---|---|---|
| mm Hg | beats/min | % | ||||
| Propranolol | -2 ± 3 | -52 ± 8** | -5.0 ± 1.7 | 10 ± 3** | 3 ± 2 | -3 ± 4 |
| Atenolol | -1 ± 3 | -82 ± 13** | -13.2 ± 2.3** | 8 ± 2** | 16 ± 4** | 11 ± 10 |
| ICI 118,551 | 1 ± 2 | -29 ± 8* | -3.8 ± 1.5** | 3 ± 3 | 5 ± 2 | 20 ± 7* |
| Atropine MeBr | 8 ± 4 | 73 ± 13** | 4.3 ± 6.7 | -13 ± 6 | 5 ± 11 | 7 ± 18 |
| Pirenzipine | -1 ± 2 | -16 ± 10 | -0.8 ± 3.9 | 3 ± 4 | 2 ± 5 | -3 ± 4 |
| Methoctramine | 9 ± 3* | 88 ± 9** | 2.5 ± 2.7 | -16 ± 3** | 7 ± 4 | 1 ± 8 |
CO, cardiac output; HqR, hindquarters vascular resistance; HR, heart rate; MAP, mean arterial pressure; SV, stroke volume; SVR, systemic vascular resistance.
↵* P < 0.05; ** P < 0.01.