The influence of pretreatment with NOS-inhibitors on SBP in mice Values represent the mean SBP of 12 to 24 mice per group.
Dose | Mean Systolic Blood Pressure | ||
|---|---|---|---|
| 0 min | 30 min | ||
| mm Hg | |||
| Vehicle | 66.5 ± 9.7 | 77.1 ± 13.6 | |
| SMTC (10 mg/kg, s.c.) | 63.5 ± 10.7 | 134.9 ± 9.8a | |
| SMTC (30 mg/kg, s.c.) | 67.5 ± 6.7 | 138.4 ± 11.5a | |
| SMTC (50 mg/kg, s.c.) | 67.6 ± 2.3 | 145.9 ± 11.0a | |
| SMTC (1.0 μg/mouse, i.c.v.) | 66.7 ± 5.1 | 70.9 ± 4.6 | |
| L-NIO (10 mg/kg, s.c.) | 65.1 ± 7.3 | 103.2 ± 16.1a | |
| L-NIO (30 mg/kg, s.c.) | 68.6 ± 9.5 | 128.4 ± 26.2a,b | |
Significance of difference: a, P < 0.001 versus vehicle control; b, P < 0.001 versus L-NIO (10 mg/kg).