ppN/OFQ-/- | Antinociceptive (higher stress-induced analgesia in group house males) in the tail-flick test; no nociceptive phenotype in individually housed males | Köster et al. (1999) |
Tail-flick test, antinociceptive in young mice (6-8 weeks), but hyperalgesic in adult mice (>12 months) | Mogil and Pasternak (2001) | |
Unchanges tolerance to morphine | Kest et al. (2001) | |
Normal responses in phase I, but increased responses in phase II of the formalin test, increased thermal sensitivity after zymosan A injection | Depner et al. (2003) | |
NOP-/- | No nociceptive phenotype in the tail-flick and acetic acid writhing test | Nishi et al. (1997) |
No nociceptive phenotype tail-flick and tail pintch test; no nociceptive phenotype hot plate, tail-flick, electric foot shock, acetic acid writhing test | Ueda et al. (1997) Mamiya et al. (1998) | |
Increased nociceptive flexor responses upon intraplantar injection of bradykinin or substance P | Inoue et al. (2003) | |
| Normal responses in phase I, but increased responses in phase II of the formalin test, increased thermal sensitivity after zymosan A injection | Depner et al. (2003) |