TABLE 1

Effects of capsazepine (10 μM) and BCTC (300 nM) on capsaicin or acidic pH induced activation of polymodal C-fiber nociceptors in isolated rat skin Data are presented as the mean ± S.E.M. Differences were tested by a paired t test. Responses to two sequential (1st and 2nd) stimuli before administration of the drug served as control.


Stimulation

Group

Activationa

P Value
CAP (0.5 μM for 30 s) Control (n = 6) 1st 49.3 ± 10.1 0.428
2nd 43.3 ± 10.7
CPZ (n = 5) Before 42.6 ± 9.5 0.005
During 7.8 ± 6.6
BCTC (n = 5) Before 41.4 ± 13.0 0.034
During 0.2 ± 0.2
Acidic pH (pH 6.1 for 5 min) Control (n = 8) 1st 17.1 ± 3.4 0.895
2nd 16.7 ± 4.1
CPZ (n = 7) Before 13.6 ± 1.7 0.812
During 13.9 ± 1.9
BCTC (n = 7) Before 18.1 ± 5.1 0.019


During
7.3 ± 1.9

  • CPZ, capsazepine; CAP, capsaicin.

  • a Action potentials evoked during stimulation.