Dose | C0 or Cmax | Tmax | AUC | CL/F | AUMC | MRT | Vss |
---|---|---|---|---|---|---|---|
MIU/kg | IU/ml | h | IU·h/ml | ml/h/kg | IU·h2/ml | h | ml/kg |
Intravenous data | |||||||
1.0 | 9.48·103 | —b | 3.29·103 | 331 | 2.60·103 | 0.80 | 273 |
(2.84·103) | (973) | (113) | (866) | (0.19) | (135) | ||
3.0 | 4.22·104 | —b | 2.36·104 | 129 | 1.76·104 | 0.76 | 99.2 |
(1.24·104) | (3.25·103) | (20.5) | (1.96·103) | (0.11) | (30.6) | ||
10.0 | 3.04·105 | —b | 1.35·105 | 75.6 | 1.12·105 | 0.84 | 64.0 |
(1.67·105) | (2.00·104) | (11.6) | (3.60·104) | (0.27) | (24.2) | ||
Subcutaneous data | |||||||
1.0 | 47.7 | 3.83 | 747 | 1.65·103 | 1.12·104 | 13.6 | —b |
(16.4) | (2.48) | (423) | (720) | (9.13·103) | (5.10) | ||
3.0 | 335 | 3.00 | 2.92·103 | 1.06·103 | 3.03·104 | 10.3 | —b |
(169) | (0.00) | (571) | (215) | (1.04·104) | (2.29) | ||
10.0 | 1.74·103 | 3.67 | 2.50·104 | 413 | 2.82·105 | 11.4 | —b |
| (605) | (2.73) | (5.17·103) | (73.3) | (4.96·104) | (0.73) |
|