Compound | Ki for [125I]DOI Binding | ||||
---|---|---|---|---|---|
5-HT2A | 5-HT2B | 5-HT2C | |||
nM | |||||
5-HT | 8.2 ± 1.6 | 13 ± 4.5 | 8.3 ± 2.6 | ||
5-MeOT | 4.7 ± 0.20 | 11 ± 3.9 | 7.5 ± 1.7 | ||
5-HOMT | 15 ± 1.5 | 22 ± 5.0 | 23 ± 5.2 | ||
5-HODMT | 10 ± 0.52 | 14 ± 2.9 | 23 ± 7.0 | ||
5-MeODMT | 15 ± 2.3 | 52 ± 2.0 | 42 ± 7.5 | ||
5-HOAMT | 12 ± 2.2 | 13 ± 3.2 | 6.6 ± 0.60 | ||
5-MeOAMT | 4.6 ± 0.79 | 7.8 ± 1.4 | 8.3 ± 2.2 | ||
rac-DOI | 0.96 ± 0.15 | 12 ± 1.0 | 7.2 ± 2.0 | ||
(R)-DOI | 0.65 ± 0.07 | 18 ± 2.7 | 4.0 ± 0.80 | ||
(S)-DOI | 3.3 ± 1.1 | 21 ± 5.2 | 10 ± 2.6 |