Data are means ± SE. | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Day | Saline | Vehicle | Single-Dose CsA | Cumulative CsA | ||||||||||||
Before | Change | Before | Change | Before | Change | Before | Change | |||||||||
MAP | ||||||||||||||||
1 | 123.5 ± 5.0 | 118.0 ± 7.0 | 113.2 ± 4.4 | 114.8 ± 2.6 | ||||||||||||
2 | 117.7 ± 3.5 | -5.8 ± 2.6 | 118.0 ± 7.6 | -5.93 ± 3.5 | 116.7 ± 5.3 | 3.5 ± 2.2 | 115.6 ± 3.2 | 0.8 ± 1.1 | ||||||||
3 | 120.9 ± 6.3 | -2.6 ± 2.0 | 112.0 ± 7.6 | -6.2 ± 2.8 | 116.4 ± 4.5 | 3.2 ± 2.5 | 119.0 ± 3.0 | 4.2 ± 0.7 | ||||||||
4 | 118.7 ± 6.2 | -4.8 ± 2.2 | 111.8 ± 8.3 | -4.9 ± 1.9 | 115.0 ± 5.5 | 1.8 ± 1.8 | 121.7 ± 2.7 | 6.3 ± 0.8# | ||||||||
5 | 119.7 ± 4.8 | -3.8 ± 1.5 | 109.5 ± 4.9 | -8.5 ± 2.6 | 111.7 ± 6.5 | -1.5 ± 2.8 | 125.5 ± 3.5 | 10.7 ± 1.1#Ψ | ||||||||
HR | ||||||||||||||||
1 | 426 ± 20 | 398 ± 10 | 415 ± 10 | 428 ± 9 | ||||||||||||
2 | 436 ± 16 | 0.0 ± 5 | 384 ± 9 | 14 ± 8 | 419 ± 11 | 4 ± 7.4 | 425 ± 7 | -3 ± 7 | ||||||||
3 | 396 ± 13 | -40 ± 9 | 365 ± 3 | -33 ± 10 | 420 ± 15 | 5 ± 8.9 | 452 ± 12 | 24 ± 9* | ||||||||
4 | 385 ± 6 | -50 ± 16 | 360 ± 10 | -37 ± 15 | 419 ± 11 | 4 ± 7.5* | 461 ± 16 | 32 ± 13*# | ||||||||
5 | 383 ± 5 | -52 ± 16 | 377 ± 13 | -21 ± 16 | 419 ± 12 | 4 ± 8.4* | 467 ± 14 | 39 ± 12*# |
↵*,#,Ψ Significant difference compared with corresponding saline, vehicle, and single-dose CsA values, respectively.