Sources and significance of plasma catechols and metabolites
Compound | Determinants | Significance |
|---|---|---|
| Norepinephrine | Sympathetic nerves | Sympathetic nerve traffic |
| Prognosis (e.g., heart failure) | ||
| Uptake-1 activity | NET function | |
| Dopamine-β-hydroxylase | DBH deficiency | |
| LAAAD | LAAAD deficiency | |
| BH4 | DHPR deficiency | |
| GTP cyclohydrolase-I deficiency | ||
| DHPG | VMAT/Vesic. Leakage | NE turnover |
| NE reuptake | NET function | |
| MAO-A | MAO-A deficiency | |
| Familial dysautonomia | ||
| Menkes disease | ||
| MHPG | DHPG | NE turnover |
| COMT activity | Altered COMT function | |
| MHPG-sulfate | MHPG | |
| SULT1A3 | ||
| MHPG-glucuronide | MHPG | Hepatic function |
| Glucuronidase | ||
| NMN | Adrenal medulla | Pheochromcytoma diagnosis |
| Sympathetic nerves | Uptake-2 activity | |
| COMT activity | Altered COMT function | |
| NMN-Sulfate | NMN | |
| SULT1A3 | ||
| VMA | MHPG | Hepatic function |
| Alcohol dehydrogenase | ||
| Aldehyde dehydrogenase | ||
| Epinephrine | Adrenal medulla | Distress |
| Shock | ||
| Glucoprivation | ||
| Calorigenesis/Obesity | ||
| Asphyxia | ||
| MN | Adrenal medulla | Pheochromocytoma diagnosis |
| 21-Hydroxylase deficiency severity | ||
| MN-sulfate | MN | |
| SULT1A3 | ||
| DA | Non-neuronal gut cells | Menkes disease diagnosis |
| Circulating L-DOPA | DBH deficiency diagnosis | |
| Sympathetic nerves | ||
| DA-sulfate | Mesenteric organs | ? Gastrointestinal TH activity |
| Diet | ||
| SULT1A3 | ||
| DOPAC | Sympathetic nerves | TH activity |
| MAO-A | MAO-A activity | |
| Extraneuronal MAO | Extraneuronal MAO activity | |
| Altered COMT function | ||
| HVA | COMT activity | Altered COMT function |
| DOPAC | ||
| 3-M-tyramine | COMT activity | Altered COMT function |
| 3-M-tyramine-sulfate | 3-M-Tyramine | |
| SULT1A3 | ||
| DOPA | Sympathetic nerves | TH activity |
| Diet | LAAAD deficiency | |
| DBH deficiency | ||
| DHPR deficiency | ||
| GTP cyclohydrolase deficiency | ||
| Melanocytes | Tyrosinase activity | |
| Malignant melanoma | ||
| ? Extraneuronal TH | Neuroblastoma diagnosis | |
| Malignant pheo. diagnosis | ||
| 3-MT | COMT | Altered COMT function |
| DOPA | ||
| 3-MT-Sulfate | 3-MT | |
|
| SULT1A3 |
|