EC50 values of test drugs for release of DA, NE, and 5-HT
Release assays were conducted as described under Materials and Methods. Values are mean ± S.D. for n = 3 experiments.
Drug | DA Release | NE Release | 5-HT Release |
|---|---|---|---|
| nM | |||
| (±)-Fenfluraminea | >10,000 | 739 ± 57 | 79.3 ± 11.5 |
| (+)-Fenfluraminea | >10,000 | 302 ± 20 | 51.7 ± 6.1 |
| (-)-Fenfluramine | >10,000 | >10,000 | 147 ± 19 |
| (±)-Norfenfluramine | 1,925 ± 295 | 168 ± 17 | 104 ± 5 |
| (+)-Norfenfluramine | 924 ± 112 | 72.7 ± 5.4 | 59.3 ± 2.4 |
| (-)-Norfenfluramine | >10,000 | 474 ± 40 | 287 ± 14 |
| Phenterminea | 262 ± 21 | 39.4 ± 6.6 | 3,511 ± 253 |