TABLE 2

Influence of P-glycoprotein inhibitors/modulators CsA and PSC833 on both materno-fetal and fetomaternal transplacental clearances (ml · min^-1 · g^-1) of Rho123 across the perfused rat-term placenta under nonsteady-state and steady-state conditions

Values are expressed as the means ± S.D. of at least four experiments.

Direction	Non-Steady-State Experiments^a			Steady-State Experiments^b
Direction		Control (1.3 μM Rho123)	(1.3 μM Rho123) + CsA (40 μM)	Control (0.65 μM Rho123)	(0.65 μM Rho123) + CsA (10 μM)	(0.65 μM Rho123) + PSC833 (10 μM)
Materno-fetal clearance (M → F)	0.05 ± 0.02	0.08 ± 0.01	0.06 ± 0.01	0.07 ± 0.01	0.10 ± 0.05
Feto-maternal clearance (F → M)	0.70 ± 0.07	0.51 ± 0.08	0.54 ± 0.08	0.39 ± 0.03	0.46 ± 0.05
Ratio (F → M/M → F)	12.94	6.32^**	8.56	5.22^*	4.47^*

↵ ^a Mean of transplacental clearances in 20 to 25 min intervals
↵ ^b Mean of transplacental clearances in 33 to 36 min intervals
↵ ^* p < 0.05
↵ ^** p < 0.01; statistically significant difference from control experiments