Effect of the different treatments on blood serum levels
Levels of sodium (Na), potassium (K), creatinine, aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT), and alkaline phosphatase (AP) levels 1 and 2 weeks after melphalan treatment. Values are median (S.D.).
Post-Treatment Levels | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Control | Systemic Melphalan | 5-min HAI Melphalan | 20-min HAI Melphalan | ||||||||||||
| 1 Week | 2 Weeks | 1 Week | 2 Weeks | 1 Week | 2 Weeks | 1 Week | 2 Weeks | ||||||||
| (n = 8) | (n = 8) | (n = 8) | (n = 8) | (n = 7)† | (n = 5)† | (n = 8) | (n = 8) | ||||||||
| Na (mmol/l) | 142 (2) | 142 (2) | 142 (3) | 141 (2) | 141 (2) | 141 (6) | 144 (2) | 141 (2) | |||||||
| K (mmol/l) | 4.9 (0.5) | 5.7 (0.8) | 4.7 (0.7) | 7.0 (1.2) | 4.6 (0.6) | 5.7 (1.5) | 5.0 (0.3) | 6.7 (1.2) | |||||||
| Creatinine (μmol/l) | 39 (2) | 36 (9) | 38 (5) | 33 (4) | 38 (10) | 36 (8) | 39 (3) | 36 (4) | |||||||
| Bilirubin (μmol/l) | 1.5 (0.6) | 1.5 (0.5) | 1.0 (0.5) | 2.0 (0.5) | 36 (26)* | 71 (59)* | 2.0 (23.8) | 2.0 (51.4) | |||||||
| ASAT (U/l) | 132 (81) | 218 (89) | 96 (16.9) | 135 (49) | 1366 (4052)* | 1376 (2727)* | 103 (175) | 131 (248) | |||||||
| ALAT (U/l) | 78 (7) | 83 (25) | 61 (27) | 87 (11) | 229 (280)* | 294 (259)* | 70 (35) | 82 (51) | |||||||
| AP (U/l) | 185 (28) | 131 (12) | 145 (42) | 181 (41) | 924 (690)* | 909 (1386)* | 178 (95) | 164 (91) | |||||||