TABLE 2

Comparison of uptake clearances in kidney slices with predicted values from the uptake study using rOat1- and rOat3-expressing LLC-PK1 cells

The observed values represent the intrinsic transport activity by kidney slices (V_max/K_m). The intrinsic transport activity of the component whose K_m value is comparable with that of the uptake in cDNA-transfected cells was used for the uptake of estrone sulfate, temocaprilat, and salicylate. The inhibitable portion was used for the observed value for AZT and ACV uptake. The details of the experiments are described under Materials and Methods.