Compound | Concentration | % Inhibition |
---|---|---|
μM | ||
Memantine | 1 | 1 |
MK-801 | 1 | 0 |
Alaproclate | 10 | 3 |
9-Aminoacridine | 10 | 20 |
9-Tetrahydroaminoacridine (9-THA) | 10 | 36 |
Benzamidine | 10 | 0 |
Arcaine | 10 | 0 |
Aminoguanidine | 10 | 1 |
Agmatine | 10 | 2 |
MGBG | 10 | 2 |
Pentamidine | 10 | 50 |
Spermine | 100 | 6 |
N 1-Dansyl-spermine (N1-DnsSpm) | 1 | 27 |
N 1-n-Octanesulfonyl-spermine | 1 | 3 |
N 1-Dansyl-spermidine | 10 | 26 |
1,10-Diamiodecane | 10 | 3 |
Aminopropyl-cyclohexylamine | 1 | 1 |
BE4444 | 1 | 0 |
MB-3 | 10 | 2 |
4-MB-3-3 | 10 | 2 |
DB-7 | 10 | 1 |
DB-10 | 10 | 4 |
DB-3-3 | 10 | 3 |
1,12-DB-3-4-3 | 10 | 6 |
4,9-DB-3-4-3 | 10 | 8 |
TB-3-4 | 1 | 1 |
The effects of each compound were tested at concentrations of 1 to 100 μM on currents through δ2(A654T) channels (in Na+-saline; background currents were measured in NMDG-saline) in oocytes voltage-clamped at −70 mV. Values are the mean for two to six oocytes for each compound. MGBG = methylglyoxyl-bis-guanylhydrazone. For the structures of bis-ethyl- and benzyl-polyamines (BE4444, MB-3, 4-MB-3-3, DB-7, DB-10, DB-3-3, 1,12-D-B-3-4-3, 4,9-DB-3-4-3, and TB-3-4) see Igarashi and Williams (1995),Igarashi et al. (1997).