Table 2

Effect of NCS-382, GHB, UMB58, UMB68, and UMB75 on [3H]GABA (10 nM) binding to GABAA receptors in rat cerebrocortical membranes and GABAB receptors in rat cerebellum membranes

CompoundPercentage of Change in Binding (n)
GABAA ReceptorGABAB Receptor
NCS-382, 100 μM−20  ± 7 (3)3  ± 3 (3)
NCS-382, 1 mM−32  ± 10 (3)1  ± 3 (3)
GHB, 100 μM−30  ± 5 (3)−23  ± 4 (6)
GHB, 1 mM−36  ± 4 (3)−41  ± 3 (6)
UMB58, 100 μM−25  ± 11 (3)−1  ± 5 (3)
UMB58, 1 mM−25  ± 5 (3)−8  ± 23 (3)
UMB68, 100 μM−29  ± 6 (3)−1  ± 9 (3)
UMB68, 1 mM−26  ± 10 (3)2  ± 5 (3)
UMB75, 100 μM−43  ± 17 (3)−16  ± 3 (3)
UMB75, 1 mM−40  ± 15 (3)−15  ± 2 (3)

Each value is mean ± S.E.M. of number of experiments indicated (n), and each experiment was performed in triplicate.