Table 2

Befloxatone-induced dose-dependent displacements of [¹¹C]befloxatone in all brain regions studied

Befloxatone Dose	[¹¹C]Befloxatone Displacements
Befloxatone Dose	Putamen	Caudate Nucleus	Thalamus	Pons	Frontal Cortex	Temporal Cortex	Cerebellum	White Matter
mg/kg	%
0.004	−11.8	−6.8	−8.9	−7.7	−2.7	−4.8	2.2	−7.6
0.020	47.5	50.4	51.0	51.6	52.4	53.5	66.7	55.1
0.040	77.3	74.8	78.5	71.0	76.3	79.4	77.9	79.1
0.040	83.9	84.8	85.5	81.7	85.5	86.7	83.8	82.6
0.100	92.1	92.9	93.6	92.6	92.5	93.2	92.8	91.2
0.400	99.8	100.1	100.6	102.0	99.8	99.3	99.6	99.4

Percentage of [¹¹C]befloxatone displacement were determined 95 min after tracer injection (see Materials and Methods). Results for each dose were calculated from one PET experiment.