Table 2

Effects of long-term treatment with sampatrilat on changes in tissue NEP and ACE activities of rats with left coronary artery ligation (CAL) and of sham-operated rats (Sham) at the 6th week after the operation

	Sham		CAL		P(ANOVA)
	Untreated	Treated	Untreated	Treated	CAL	Treated	Inter
n	6	6	6	6
NEP activity (pmol/mg protein/min) scar			2.07 ± 0.57	0.10 ± 0.04^2-150
left ventricle	3.38 ± 0.64	0.745 ± 0.63^2-150	1.61 ± 0.32	<0.1^2-150	0.0029	<0.0001	N.S.
septum	0.94 ± 0.36	0.83 ± 0.21^2-150	1.12 ± 0.20	<0.1^2-150	N.S.	0.0146	0.0417
right ventricle	0.34 ± 0.15	0.37 ± 0.17	1.29 ± 0.37	<0.1^2-150	N.S.	0.0001	0.0073
lung	83.3 ± 9.5	44.9 ± 6.7	49.1 ± 3.0	29.0 ± 2.0^2-150	0.0005	0.0001	N.S.
kidney	3154 ± 357	1293 ± 184^2-150	2196 ± 289	288 ± 99^2-150	0.0009	0.0021	N.S.
ACE activity (nmol/mg protein/min)
Lung	13.8 ± 0.3	5.7 ± 1.3^2-150	4.2 ± 0.5	1.9 ± 0.4^2-150	<0.0001	<0.0001	0.0014

Values represent the means ± S.E.M.

↵2-150 P < 0.05 vs. corresponding untreated group.