Parameter | Hours of Dark Cycle | Cumulative | |||
---|---|---|---|---|---|
1–3 | 4–6 | 7–9 | 10–12 | ||
Eating duration, min | |||||
Vehicle | 8.1 ± 1.5 | 16.0 ± 1.6 | 7.6 ± 1.5 | 7.2 ± 1.2 | 38.9 ± 2.4 |
0.01 μg | 8.6 ± 1.9 | 16.1 ± 1.3 | 5.2 ± 1.9 | 8.4 ± 2.3 | 38.3 ± 3.1 |
0.1 μg | 8.7 ± 1.5 | 13.2 ± 1.0 | 8.1 ± 1.9 | 6.1 ± 1.2 | 36.3 ± 1.8 |
1 μg | 10.1 ± 1.4 | 11.9 ± 2.2 | 7.2 ± 1.2 | 7.2 ± 1.1 | 36.3 ± 2.7 |
10 μg | 8.1 ± 0.7 | 9.1 ± 1.3a b | 6.7 ± 1.6 | 4.6 ± 1.3 | 28.5 ± 2.6a b |
Drinking duration, min | |||||
Vehicle | 2.3 ± 0.9 | 16.9 ± 2.1 | 8.1 ± 2.2 | 4.9 ± 1.3 | 32.1 ± 2.7 |
0.01 μg | 1.8 ± 0.9 | 11.0 ± 1.9a | 6.0 ± 2.5 | 4.9 ± 1.7 | 23.8 ± 2.2a |
0.1 μg | 2.8 ± 2.0 | 8.2 ± 2.2a | 9.1 ± 2.8 | 4.5 ± 1.6 | 24.5 ± 3.9a |
1 μg | 1.5 ± 0.9 | 8.4 ± 2.9a | 6.9 ± 1.9 | 7.4 ± 2.5 | 24.1 ± 3.9a |
10 μg | 1.3 ± 0.5 | 6.1 ± 2.0a | 5.9 ± 2.4 | 2.9 ± 1.1 | 16.3 ± 3.9a |
Effects of i.c.v. pretreatment with hUcn II 90 min prior to the dark cycle on the mean (± S.E.M.) duration of nose-poke responding for food and water during the dark cycle in male Wistar rats (n= 10, full Latin square design).
Statistically significant differences:
a,b, significant differences from vehicle and 0.01 μg, respectively, p < 0.05, Fisher's protected least significant difference test.