Effects of COX inhibition on GFR and fractional clearance of electrolytes in rats with PHN
| Inulin Clearance | FENa | FEK | p-Na | p-K | |
|---|---|---|---|---|---|
| μl/min | mEq/l | ||||
| Vehicle | 2.7 ± 0.4 (8) | 0.44 ± 0.19 (6) | 37 ± 7 (6) | 148 ± 1 (6) | 4.2 ± 0.2 (6) |
| DFU1 | 2.9 ± 0.5 (8) | 0.24 ± 0.11 (3) | 21 ± 3 (3) | 148 ± 3 (3) | 4.7 ± 0.5 (3) |
| DFU10 | 2.3 ± 0.3 (8) | 0.18 ± 0.09 (5) | 24 ± 8 (5) | 148 ± 5 (5) | 4.4 ± 0.4 (5) |
| Indo | 2.5 ± 0.2 (7) | 0.16 ± 0.05 (4) | 26 ± 3 (4) | 149 ± 3 (4) | 4.5 ± 0.1 (4) |
Numbers in parenthesis indicate the number of rats studied. There are no significant differences among groups in any of the parameters.
FENa, fractional excretion of Na; FEK; fractional excretion of K; p-Na, plasma Na concentration; p-K, plasma K concentration.