Table 3

Recoveries of noneliminated reference indicators and labeled hippurate and benzoate after injection of MID doses of [3H]hippurate and [14C]benzoate during retrograde perfusion were compared with those published by Schwab et al. (2001) for retrograde perfusiona

Tracer Recoveries % (HA + BA)
51Cr-labeled RBCs 125I-labeled AlbuminLabeled Sucrose 2H2OHippurate (HA)Benzoate (BA)Hippurate + BenzoateHA3-bBA3-c
Hippurate Injection
 Retrograde (n = 8)0.97  ± 0.130.91  ± 0.081.11  ± 0.250.98  ± 0.040.96  ± 0.06
 Prograde (n= 7)1.04  ± 0.111.02  ± 0.130.99  ± 0.101.01  ± 0.121.03  ± 0.08
Benzoate Injection
 Retrograde (n = 8)1.03  ± 0.090.92  ± 0.071.29  ± 0.190.49  ± 0.090.45  ± 0.050.94  ± 0.0952  ± 548  ± 5
Prograde (n = 7)1.09  ± 0.101.02  ± 0.130.95  ± 0.21*0.42  ± 0.120.49  ± 0.160.90  ± 0.2149  ± 1151  ± 11

  • 3-150 P < 0.05, prograde vs. retrograde.

  • a Data were mean ± S.D. of fractions of complete recovery (AUC/perfusate flow rate).

  • ↵3-b Ratio of recoveries: HA/(HA + BA).

  • ↵3-c Ratio of recoveries: BA/(HA + BA).