Cummins ER Fisher ER Model-Predicted ER | |||
---|---|---|---|
Control | 0.45 ± 0.11 | 0.75 ± 0.06 | 0.77 |
PSC833 | 0.42 ± 0.07 | 0.64 ± 0.07* | 0.65 |
Midazolam | 0.33 ± 0.06* | 0.57 ± 0.10* | 0.59 |
Ketoconazole | 0.01 ± 0.01* | 0.02 ± 0.02* | 0.17 |
Cummins, Fisher, and model-predicted extraction ratios of verapamil were calculated with eqs. 3, 4, and 5, respectively. Observed data are the mean and S.D. of n = 4–7 determinations.
2-150 Significantly different from respective control ER (P < 0.05).