Table 1

Mean pharmacokinetic parameters of acetothiolutamide in male rats after intravenous and subcutaneous administration

Parameteri.v.Subcutaneous
5 mg/kg (n = 5)10 mg/kg (n = 5)1-a10 mg/kg (n = 4)
AUC0–∞ (μg · min/ml)131  ± 70229  ± 54298  ± 61
AUMC0–∞(μg · min2/ml)3800  ± 21607430  ± 220051400  ± 14300
t 1/2(min)25.5  ± 10.526.4  ± 7.086.6  ± 40.01-b
MRT (min)32.2  ± 18.033.2  ± 10.0174  ± 42
CL (ml/min/kg)46.3  ± 20.445.4  ± 9.7
V ss (l/kg)1.68  ± 0.811.78  ± 0.78
F s.c.(%)100

Values represent mean ± S.D.

  • MRT, mean residence time.

  • ↵1-a  Not significantly different from the 5 mg/kg dose group in t1/2, MRT, CL, orVss, as tested by single factor ANOVA (α = 0.05).

  • ↵1-b  Significantly different fromt1/2 after i.v. administration of 10 mg/kg (p < 0.05).