Parameter5-a | Dosing Group | ||
---|---|---|---|
MRK-1 Alone | MRK-1 + 10 mg/kg Quinidine | MRK-1 + 30 mg/kg Quinidine | |
2 mg/kg MRK-1 | |||
AUC0→∞(ng · h/ml) | 640 ± 444 | 1744 ± 619 | 1861 ± 344 |
C max (ng/ml) | 144 ± 106 | 530 ± 133 | 714 ± 161 |
K a(h−1) | 2.3 ± 1.0 | 5.2 ± 2.5 | 11 ± 4.4 |
K el (h−1) | 0.37 ± 0.07 | 0.43 ± 0.06 | 0.41 ± 0.03 |
T max (h) | 0.94 ± 0.21 | 0.52 ± 0.16 | 0.32 ± 0.09 |
10 mg/kg MRK-1 | |||
AUC0→∞(ng · h/ml) | 5890 ± 1615 | N.D.5-b | 11,773 ± 2356 |
C max (ng/ml) | 3565 ± 533 | N.D. | 3654 ± 1024 |
K obs (h−1) | 5.1 ± 2.6 | N.D. | 6.6 ± 1.4 |
K el (h−1) | 0.44 ± 0.11 | N.D. | 0.38 ± 0.02 |
T max (h) | 0.53 ± 0.17 | N.D. | 0.46 ± 0.06 |