Pharmacokinetic Parameter | MRK-1 Dose (2 mg/kg p.o.) | MRK-1 Dose (10 mg/kg p.o.) | ||
---|---|---|---|---|
Control | +Ritonavir | Control | +Ritonavir | |
Rats | ||||
AUC0→∞(ng · h/ml) | 978 ± 727 | 6198 ± 1314 | 12,250 ± 5115 | 52,330 ± 16,420 |
C max (ng/ml) | 321 ± 214 | 1561 ± 364 | 4085 ± 2159 | 13,360 ± 6312 |
T max (h) | 0.4 ± 0.1 | 2.0 ± 1.4 | 1.1 ± 0.6 | 1.6 ± 1.6 |
Rhesus Monkeys | ||||
AUC0→∞(ng · h/ml) | 936 ± 360 | 5650 ± 1873 | 7865 ± 3842 | 42,863 ± 7066 |
C max(ng/ml) | 569 ± 323 | 622 ± 175 | 2784 ± 1664 | 3587 ± 802 |
T max (h) | 0.4 ± 0.1 | 3.3 ± 1.2 | 0.6 ± 0.3 | 3.0 ± 1.2 |
All values are mean ± S.D.