[3H]QNB binding (fentomoles per milligram of tissue)
| 2 Weeks Post-Treatment | ||||
|---|---|---|---|---|
| Control | PB | Sarin | Sarin + PB | |
| Somat sens Ctx | 132.4 ± 9.5 | 125.4 ± 6.1 | 112.2 ± 11.2 | 114.6 ± 10.8 |
| Temporal Ctx | 125.4 ± 5.0 | 125.6 ± 4.2 | 96.7 ± 14.5 | 105.6 ± 7.5 |
| Piriform Ctx | 121.8 ± 7.9 | 107.5 ± 2.8 | 93.2 ± 12.9 | 98.0 ± 5.9 |
| Hippocampus | 115.9 ± 3.5 | 114.4 ± 4.7 | 92.2 ± 10.52-150 | 95.7 ± 6.6 |
| Caudate-Putamen | 177.8 ± 12.9 | 171.1 ± 7.6 | 128.8 ± 15.72-150 | 158.2 ± 12.1 |
| Thalamus | 68.6 ± 3.5 | 61.6 ± 1.5 | 60.1 ± 8.4 | 53.9 ± 4.2 |
| Hypothalamus | 42.1 ± 5.0 | 38.3 ± 1.4 | 29.3 ± 4.4 | 36.5 ± 3.0 |
| Mesencephalon | 48.9 ± 2.3 | 42.9 ± 1.7 | 32.5 ± 4.42-150 | 44.3 ± 3.6 |
| Cerebellum | 9.9 ± 0.7 | 10.4 ± 1.0 | 6.2 ± 1.2 | 9.4 ± 1.3 |
| Medulla | 36.4 ± 1.6 | 35.7 ± 1.4 | 36.7 ± 8.1 | 35.8 ± 3.0 |
| 4 Weeks Post-Treatment | ||||
|---|---|---|---|---|
| Control | PB | Sarin | Sarin + PB | |
| Somat sens Ctx | 125.9 ± 7.2 | 123.9 ± 3.9 | 131.9 ± 5.22-150 | 107.8 ± 6.9 |
| Temporal Ctx | 121.1 ± 6.4 | 123.7 ± 2.7 | 121.3 ± 10.3 | 106.1 ± 6.0 |
| Piriform Ctx | 111.7 ± 4.6 | 111.7 ± 3.2 | 110.9 ± 6.3 | 107.2 ± 4.2 |
| Hippocampus | 105.4 ± 5.7 | 118.0 ± 3.2 | 107.9 ± 8.3 | 105.8 ± 6.3 |
| Caudate-Putamen | 170.4 ± 6.5 | 182.0 ± 4.5 | 187.5 ± 9.7 | 160.2 ± 6.2 |
| Thalamus | 64.1 ± 3.1 | 61.4 ± 1.8 | 58.8 ± 3.0 | 60.1 ± 3.3 |
| Hypothalamus | 33.3 ± 2.4 | 39.4 ± 1.8 | 39.5 ± 1.8 | 36.0 ± 3.5 |
| Mesencephalon | 51.3 ± 3.0 | 44.3 ± 1.5 | 48.1 ± 1.7 | 45.4 ± 3.2 |
| Cerebellum | 10.1 ± 0.8 | 9.5 ± 0.4 | 10.1 ± 0.8 | 10.2 ± 1.3 |
| Medulla | 36.9 ± 3.5 | 35.1 ± 2.3 | 41.2 ± 2.5 | 43.0 ± 3.4 |
| 16 Weeks Post-Treatment | ||||
|---|---|---|---|---|
| Control | PB | Sarin | Sarin + PB | |
| Somat sens Ctx | 97.1 ± 9.2 | 108.3 ± 4.0 | 116.3 ± 11.6 | 101.4 ± 4.2 |
| Temporal Ctx | 113.3 ± 4.7 | 117.4 ± 3.5 | 118.8 ± 8.6 | 117.1 ± 5.0 |
| Piriform Ctx | 102.2 ± 2.6 | 108.1 ± 3.9 | 109.5 ± 7.9 | 95.6 ± 3.4 |
| Hippocampus | 109.2 ± 5.7 | 120.4 ± 5.2 | 109.9 ± 8.5 | 115.3 ± 2.4 |
| Caudate-Putamen | 159.8 ± 7.5 | 167.8 ± 3.2 | 157.1 ± 11.3 | 163.4 ± 7.7 |
| Thalamus | 56.8 ± 2.9 | 61.8 ± 2.1 | 56.6 ± 3.8 | 59.9 ± 3.4 |
| Hypothalamus | 37.1 ± 1.7 | 35.9 ± 1.8 | 38.7 ± 3.2 | 29.2 ± 1.1 |
| Mesencephalon | 36.5 ± 4.0 | 41.9 ± 0.8 | 45.4 ± 3.6 | 36.1 ± 1.2 |
| Cerebellum | 10.8 ± 2.2 | 7.9 ± 0.5 | 10.7 ± 1.0 | 9.5 ± 0.4 |
| Medulla | 30.4 ± 1.2 | 32.3 ± 1.2 | 37.1 ± 2.8 | 30.2 ± 1.6 |
Data shown are mean ± S.E. of 12 animals per experimental condition and time post-treatment
Ctx, cortex; Somat sens, somatosensory.
↵2-150 Statistically significant by ANOVA and Fisher's LSD tests.