Table 1

Chlamydocin inhibits cell proliferation in various cell lines: MTT-based assay as described under Materials and Methods

Cell lineOriginIC50
nM
A2780 (p53 wild type)Ovarian0.36  ± 0.15
Malme-3M (p53 wild type)Melanoma45  ± 2.5
MCF-7 (p53 wild type)Breast5.3  ± 2.3
HT-29 (p53 inactivated)Colon4.3  ± 0.8
HeLa (p53 inactivated)Cervix14  ± 2
H1299 (p53 null)Lung4  ± 2
K562/C1000 (p53 null)Leukemia0.76  ± 0.06