Drug | Route | Dose | Placing/Stepping | Pinnae/Blink | Catalepsy |
---|---|---|---|---|---|
Morphine | i.t. | 0.3 μg | 0 | 0 | 0 |
i.t. | 3 μg | 0 | 0 | 0 | |
i.t. | 10 μg | 0 | + | + | |
i.t. | 30 μg | 0 | ++ | ++ | |
DVL 2DAL 5LanEnk | i.t. | 0.1 μg | 0 | 0 | 0 |
i.t. | 1 μg | 0 | 0 | 0 | |
i.t. | 10 μg | 0 | 0 | 0 | |
i.t. | 30 μg | 0 | 0 | 0 | |
Morphine | i.p. | 0.1 mg/kg | 0 | 0 | 0 |
i.p. | 1 mg/kg | 0 | + | + | |
i.p. | 3 mg/kg | 0 | ++ | ++ | |
DVL 2DAL 5LanEnk | i.p. | 0.1 mg/kg | 0 | 0 | 0 |
i.p. | 1 mg/kg | 0 | 0 | 0 | |
i.p. | 3 mg/kg | 0 | 0 | + |
0, observed in no animals; +, observed in less than 50% of rats; ++, observed in greater than 50% of rats.