Effect of RWJ-58259 administration on the hematological profile of cynomolgus monkeys
| Vehicle-Treated | Drug-Treated | |||
|---|---|---|---|---|
| Baseline | 65 min Post | Baseline | 65 min Post | |
| RBC (106/μl) | 5.21 ± 0.79 | 4.23 ± 0.68 | 5.02 ± 0.40 | 4.28 ± 0.61 |
| HCT (%) | 36.62 ± 5.12 | 29.66 ± 4.58 | 34.82 ± 0.94 | 29.70 ± 2.74 |
| PLT (103/μl) | 329 ± 98 | 281 ± 113 | 311 ± 141 | 256 ± 106 |
| WBC (103/μl) | 8.14 ± 3.58 | 8.30 ± 2.88 | 7.3 ± 1.02 | 8.54 ± 1.46 |
Blood samples were obtained pre- and postvehicle or compound administration. Results are mean ± S.E. (n = 5 animals/treatment group).