Table 4

Ratio of intercompartmental rate constants (basolateral efflux/uptake) for CDF disposition in livers from wild type and Mrp2-deficient rats in the presence or absence of probenecid

Treatment	Ratio in Wild-Type Rats	Ratio in TR⁻ Rats
CDFDA control	0.13 ± 0.17	15.3 ± 6.8^4-a
CDFDA + probenecid (260 μM)	3.4 ± 1.6^4-b	5.5 ± 3.3^4-b
CDFDA + probenecid (4 mM)	N/A^4-c	2.4 ± 0.7^4-b

Values are mean ± S.D., n = 3/group.

↵4-a p < 0.05, comparison of mutant to wild-type.
↵4-b p < 0.05, values compared with control in relevant group.
↵4-c CDF disposition in wild-type rat livers was not assessed at 4 mM probenecid.