Effect of Y-27632 (0.8 mg/kg/h) on urine volume, GFR excretion of sodium, and potassium, and blood pressure during the clearance study in adult rats
| WKY | SHR | |||
|---|---|---|---|---|
| Vehicle | Y-27632 | Vehicle | Y-27632 | |
| Urine volume (ml/h/100 g b.wt.) | ||||
| Control | 0.49 ± 0.09 | 0.38 ± 0.05 | 0.36 ± 0.08 | 0.44 ± 0.12 |
| Experiment | 0.41 ± 0.11 | 0.69 ± 0.061-150 | 0.31 ± 0.12 | 0.67 ± 0.131-150 |
| GFR (ml/min/100 g b.wt.) | ||||
| Control | 0.89 ± 0.10 | 0.82 ± 0.09 | 0.77 ± 0.10 | 0.78 ± 0.12 |
| Experiment | 0.84 ± 0.11 | 0.91 ± 0.12 | 0.83 ± 0.12 | 0.80 ± 0.13 |
| Na excretion (mEq/h/100 g b.wt.) | ||||
| Control | 0.052 ± 0.007 | 0.049 ± 0.008 | 0.034 ± 0.01 | 0.033 ± 0.009 |
| Experiment | 0.048 ± 0.009 | 0.089 ± 0.0121-150 1-159 | 0.031 ± 0.011 | 0.091 ± 0.0191-150 1-159 1-252 |
| FENa (%) | ||||
| Control | 0.40 ± 0.05 | 0.44 ± 0.05 | 0.26 ± 0.06 | 0.28 ± 0.07 |
| Experiment | 0.38 ± 0.08 | 0.88 ± 0.081-150 1-159 | 0.27 ± 0.07 | 0.74 ± 0.121-150 1-159 1-252 |
| FEK (%) | ||||
| Control | 15.3 ± 2.0 | 15.7 ± 1.7 | 16.4 ± 3.7 | 14.2 ± 3.3 |
| Experiment | 13.4 ± 2.5 | 14.4 ± 1.6 | 14.6 ± 1.9 | 13.9 ± 2.3 |
| Mean arterial blood pressure (mm Hg) | ||||
| Control | 117.5 ± 4.0 | 113.4 ± 5.1 | 155.5 ± 3.81-252 | 154.2 ± 4.21-252 |
| Experiment | 111.5 ± 4.6 | 114.7 ± 4.3 | 162.8 ± 5.21-252 | 161.8 ± 4.61-252 |