Antithrombotic effects of SSR182289A and ximelagatran following oral administration in the rabbit venous (Wessler) thrombosis model
| Treatment Group | Dose | n | Wet Thrombus Weight (Mean ± S.E.M.) |
|---|---|---|---|
| mg/kg p.o. | mg | ||
| Control | 6 | 164.7 ± 18.4 | |
| Ximelagatran | 3 | 6 | 227.7 ± 23.1 |
| 10 | 6 | 41.0 ± 21.52-150 | |
| 30 | 5 | 0.0 ± 0.02-150 | |
| Control | 15 | 183.0 ± 14.8 | |
| SSR182289A | 2.67 | 6 | 162.6 ± 29.5 |
| 8.9 | 6 | 57.1 ± 36.22-150 | |
| 30 | 5 | 0.0 ± 0.02-150 |
↵2-150 P < 0.01 versus control group.