Strain | Baseline Latency | Morphine | U50,488 | WIN55,212-2 | Epibatidine | Clonidine |
---|---|---|---|---|---|---|
s | mg/kg | mg/kg | mg/kg | μg/kg | mg/kg | |
129P3 | 3.17 (0.10) | 10.5 (8.5–13.0) | 24.5 (16.7–35.8) | 2.7 (2.0–3.7) | 25.0 (18.8–33.1) | 0.16 (0.12–0.23) |
A | 3.16 (0.10) | 14.2 (12.1–16.8) | 27.1 (19.8–37.0) | 2.5 (1.9–3.2) | 16.2 (12.1–21.7) | 0.20 (0.16–0.25) |
AKR | 2.85 (0.08) | 15.3 (10.8–21.7) | 31.7 (23.5–42.8) | 91.9 (41.8–202.4) | n.a.d. | 0.20 (0.12–0.34) |
C57BL/10 | 2.43 (0.06) | 24.3 (18.2–32.5) | 38.7 (29.6–50.8) | 47.9 (33.0–69.5) | 65.3 (59.9–71.2) | 1.36 (0.88–2.09) |
C57BL/6 | 2.12 (0.09) | 23.3 (17.8–30.6) | 54.6 (42.8–69.7) | 17.2 (12.7–23.3) | 45.1 (31.5–64.5) | 1.53 (0.98–2.39) |
BALB/c | 3.64 (0.11) | 16.8 (14.0–20.2) | 22.9 (19.5–26.9) | 4.1 (3.0–5.6) | 16.1 (12.4–21.0) | 0.27 (0.20–0.37) |
C3H/He | 2.40 (0.07) | 11.1 (9.5–12.9) | 43.9 (29.6–64.9) | 5.0 (3.4–7.5) | 98.8 (91.1–107.0) | 0.31 (0.20–0.48) |
C58 | 2.56 (0.07) | 38.5 (23.0–64.6) | 56.7 (39.0–82.1) | 21.3 (15.6–29.0) | 58.6 (39.8–86.3) | 1.31 (1.06–1.61) |
CBA | 2.29 (0.07) | 13.8 (12.0–15.8) | 50.7 (38.0–67.8) | 8.5 (7.7–9.3) | n.a.d. | 0.40 (0.22–0.71) |
DBA/2 | 2.80 (0.09) | 11.0 (8.9–13.6) | 24.1 (19.8–29.4) | 3.2 (1.8–5.7) | 26.6 (21.2–33.5) | 0.22 (0.16–0.30) |
RIIIS | 3.17 (0.10) | 13.7 (10.2–18.5) | 25.1 (18.2–34.8) | 8.4 (5.0–14.1) | 32.9 (20.6–52.5) | 1.21 (0.80–1.84) |
SM | 2.30 (0.08) | 24.7 (19.9–30.6) | 36.1 (30.3–43.0) | 13.6 (11.9–15.5) | 46.7 (31.7–68.6) | 1.08 (0.81–1.44) |
Rangea | 1.7 | 3.7 | 2.5 | 36.8 | 6.11-150 | 9.6 |
Heritabilityb | 0.26 ± 0.08 | 0.14 ± 0.05 | 0.12 ± 0.05 | 0.34 ± 0.09 | 0.40 ± 0.10 | 0.40 ± 0.10 |
n.a.d., not accurately determined (see the text).
a Highest value divided by lowest value.
b See the text for details.
↵1-150 Likely an underestimate, since AKR and CBA strains were even more insensitive.