Influence of different neurohumoral antagonists on the LES smooth muscle relaxation by CL 316243 (3 × 10−5 M)
| Experiment | Percentage of Fall in LES Tension |
|---|---|
| Control | 76.4 ± 3.61-a |
| Tetrodotoxin (1 × 10−6 M) (neurotoxin) | 80.5 ± 4.3 |
| Hexamethonium (1 × 10−4M) (ganglionic blocker) | 81.2 ± 4.1 |
| Phentolamine +guanethidine (3 × 10−6 M) (adrenergic blockers) | 79.7 ± 3.8 |
| Atropine (1 × 10−6 M) (anticholinergic) | 76.6 ± 5.2 |
| Haloperidol (1 × 10−5 M) (dopamine antagonist) | 80.4 ± 2.8 |
| Pyrilamine + cimetidine (1 × 10−5 M) (antihistamines) | 85.3 ± 6.2 |
| Indomethacin (1 × 10−5 M) (cycloxygenase inhibitor) | 76.9 ± 5.3 |
↵1-a The values represent mean ± S.E. of five to eight observations. None of the antagonists examined had any significant effect on CL 316243-induced relaxation of the LES smooth muscle during control experiments (p > 0.05).